EXPERIENCE IN HUMANS
The first human study appeared in 2009 when Coleman et al. reported results after cryolipolysis had been applied to love handles in a single session to ten patients, each patient being their own control. A session takes less than an hour and does not require anesthesia. With a single treatment subjects had a 20% reduction after two months and 25% reduction at six months in the fat layer as assessed by ultrasound. The lipolytic effect of treatment takes place within about two to four months. It appears primarily applicable to limited discrete fat bulges.
Transient local redness, bruising and numbness of the skin are common side effects of the treatment and are expected to subside.] Typically sensory deficits will subside within a month. The effect on peripheral nerves was investigated and failed to show permanent detrimental results No serious long-lasting side effects were encountered during follow-up time of six months.
In September 2010, the Food and Drug Administration approved the cryolipolysis procedure